Détails Publication
Liver Cancer Survival and Prognostic Factors in a High Endemic Area of Hepatitis B,
Discipline: Médecine clinique
Auteur(s): Kounpièlimè Sosthène Somda1,2*, Abdoul Fataho Kabore1, Aboubacar Coulibaly1,2, Sandrine Marie Odile Soudre2, Toussaint Vebamba1, Christiane Bere1, Arsène Roger Sombie1,2
Renseignée par : SOMDA Kounpielime Sosthène
Résumé

Abstract
Background: Hepatitis B infection is a global public health problem especially
in developing countries with high prevalence, and liver cancer is its most
feared complication. In these countries the majority of infections occur in
early childhood with the corollary of a frequent transition to chronicity and
increased risk of liver cancer. For various reasons, these cancers are diagnosed
at a late stage, resulting a high mortality rate. The aim of this work was to study
survival and prognostic factors in patients with liver cancer in the gastroenterology
department at the Yalgado Ouédraogo University Hospital in Burkina
Faso. Patients and Methods: it was a cross-sectional, descriptive and analytical
study with retrospective collection in the Gastroenterology department at
the Yalgado Ouédraogo University Hospital. The collection period was 12
months, from January 1st to December 31st 2023. The study population consisted
of all the patients who had been hospitalized in the Gastroenterology
department during the period. Any patient in whom the diagnosis of liver cancer
was established was included. The diagnosis was established on clinical and
paraclinical criteria. Patients hospitalized with another diagnosis were excluded.
The data were analyzed by Epi-Info software. Texts, graphs and table
have been produced by Word and Excel Software 2016. Quantitative variables
were expressed as mean and standard deviation, and qualitative variables as
number and percentage. A difference was considered significant when the pvalue
was less than 5%. Results: During the study period, 339 patients were
hospitalized,107 of whom had liver cancer, representing a prevalence of
31.56%. The mean age was 40.56 years. Men were the most affected, with a sex
ratio of 4.6. The mean antecedents were alcohol 33.96%, and hepatitis B. The
majority (59.43%) of our patients consulted between 1 and 3 months. Seventy
percent of patients were under 60 years old. Hepatitis virus B and/or C were found in 89.7% of cases; 60.74% of our patients were in stage D of BCLC classification;
66.33% had died. The median survival was 2 months, with overall
survival at 6 months estimated at 30% and zero at 14 months. In the multivariate
cox model, after adjusting for the other covariables, Child-Pugh stage C,
BCLC stage D and sex male were statistically associated as prognostic factors
of death with Hazar ratios of 2.66; 3.75 and 2.21 respectively. Conclusion:
Liver cancer is often diagnosed late in our context with a median survival less
than 2 months. Viral hepatitis is the main cause so, preventive measures
should be taken as well to decrease liver cancer prevalence

Mots-clés

Liver Cancer, Survival, Prognostic Factors, Burkina Faso

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