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In context of hypertension, research in African traditional medicine allows the identification of safe and effective recipes that lead to the development of phytomedicines or the isolation of molecules that can be used in managing of hypertensive patients.
Objectives: This study aims at formulating and evaluating tablets based on Lannea microcarpa Engl. et K. Krause (Anacardiaceae) extracts for arterial hypertension therapy.
Methodology: Formulations of conventional release tablets containing 250mg and 500mg of extract were made. Several excipients were tested in several steps and wet granulation was performed. A formulation containing a diluent/disintegrant (corn starch), a binding agent (PVP K30) and a lubricant (magnesium stearate) was made. Then a flow agent (colloidal silica) was associated with the formulations of the first step. Finally, the colloidal silica of the previous formulations has been replaced by an anti-adhesive, the talc.
Discussion: The average masses of the 250 mg tablets varied from 263.187 mg ± 16.4 to 379.979 ± 13.1 with coefficients of variation between 2.72% and 6.23%. The average masses of the 500mg tablets varied from 561.047mg ± 15.13 to 783.388 ± 33.82 with coefficients of variation between 2.05% and 4.95%. These tablets had disintegration times of less than 15 minutes. The friability indices (< 1%) of the tablets of formulations FA6, 11, 17 and 18 as well as FB1, 2, 7, 8 and 15 alone complied with the specifications of the European Pharmacopoeia 10th edition. The mean contents were 0.378900 ± 0.010609 mg gallic acid equivalent (GAE)/tablet and 0.757 0.0211 mg GAE/tablet, respectively for the 250mg and 500mg tablets. The individual content of each tablet unit of both strengths was between 85 percent and 115 percent of the mean content and complied with the requirements of the European Pharmacopoeia 10th edition. These analyses led to the choice of FA6 and FB2 as the optimal formulation.
Conclusion: These results show the feasibility of the extracts of the plant in pharmaceutical form for the treatment of arterial hypertension.

Arterial hypertension; Extracts; Formulations; Lannea macrocarpa; Tablets