The aim of this study was to perform phytochemical investigations of three medicinal plants oriented against antioxidant and anti-inflammatory activities. The spectrophotometer was used for quantification tests. The antioxidant activity was evaluated by ABTS●+, DPPH● and FRAP method. The acute toxicity (OECD 423) and the anti-edematous activity were performed on NMRI mice. Phytochemical screening allowed the identification of some chemical groups. Ethanolic extracts of Guiera senegalensis showed the best total phenolic contents (97.77±0.30 g EAA/100 g extract) and the best antioxidant activity with ABTS●+ (IC50: 3.86±0.17 μg/mL), DPPH● (IC50: 12.20±0.02 μg/mL) and FRAP (32.80±0.55 mmol EAA/g) methods. The extracts showed an inhibitory effect on 15-lipoxygenase activity (14.67 to 99.49% at 100 µg/mL). The aqueous decoction (68.10%) and the ethanolic macerate (74.21%) of the recipe showed a good percentage of inhibition of edema from the 5th hour at a dose of 400 mg/kg b.w. These results could constitute a solid scientific basis justifying the traditional uses of these plants

Phytochemical, antioxidant activities, acute toxicity and carrageenan edema test