Introduction : Preeclampsia is responsible for 60.000
deaths worldwide. In Burkina Faso, it is among the 4 leading
causes of maternal deaths. Mutations in the V Leiden gene
(FVL G1691A) and the prothrombin gene (FII G20210A) are
frequently found in hereditary hypercoagulability disorders
that promote thrombosis and preeclampsia. The objective
of this study was to establish a correlation between
prothrombin FII gene polymorphisms and preeclampsia in
women in the gravido-puerperium period in Burkina Faso.
Methodology: this was a case-control study that included
100 samples including 28 cases of severe preeclampsia
and 72 controls. After extraction of genomic DNA using a
“Ribo Sorb” mini kit, the G20210A mutation of prothrombin
factor II was searched for by real-time PCR.
Results: The genotype frequencies in the study
population of wild type homozygotes (bb), heterozygotes
(ab) and mutated homozygotes (aa) were 93%; 7% and
00% respectively. The genotype frequencies of wild
type homozygotes (bb) and heterozygotes (ab) were
respectively 100% and 0% in cases and 97% and 7% in
controls (p = 0.32 ; OR = 0.22).
Conclusion: This study established for the first time
the frequencies of prothrombin FII gene genotypes
and preeclampsia in Burkina Faso. She found the low
prevalence of the prothrombin FII gene mutation in the study
population and the modest link between thrombophilia and
preeclampsia. Future studies with more representative
samples of the population are necessary to confirm this
and identify a link between prothrombin factor II and the
severity of preeclampsia.

Gene; FII; Prothrombin; G20210A mutation; Preeclampsia; Burkina Faso