Fructosamine Profile in Regular Blood Donors at the Bobo-Dioulasso Regional Blood Transfusion Centre, Burkina Faso

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Résumé

Introduction: Fructosamine is a stable ketoamine, formed by the reaction between glucose and the amino group of proteins (mainly albumin, but also globulins and lipoproteins). It indicates average blood glucose concentrations of 2 to 3 weeks for monitoring and controlling diabetes. However, studies on fructosamine based on the characteristics of Burkinabè are still rarely documented. With this in mind, the aim of this study was to investigate the fructosamine profile in regular blood donors from the town of Bobo-Dioulasso (Burkina Faso). Material and methods: This was a descriptive and analytical cross-sectional study with a collection period from 10 August 2024 to 10 September 2024. The study population consisted of fasting adult regular blood donors from Burkina Faso residing in the city of Bobo-Dioulasso, collected at the Bobo-Dioulasso Regional Blood Transfusion
Centre. Fructosamine was determined by the colorimetric method using the Cobas® 6000 analyser. The data were analysed using R studio 4.3.3 software so that medians were calculated and reference values were determined at the 2.5 thand 97.5 thpercentile.
Results-discussion: A total of 60 regular blood donors, equally distributed by gender, were selected. The mean age of the regular blood donors was 28.28±7.72 years (min = 19 years and max=52 years) while the mean number of donations was 6.97±8.50 (min=2 and max=61). Median fructosamine values were 272.5 µmol/L while the 2.5 thand 97.5 thpercentiles were 247.9 µmol/L and 314.77 µmol/L. The fructosamine ranges in our study population were higher than the reference values proposed by the reagent kit manufacturer and those proposed in the literature. There was no significant difference between the mean fructosamine concentrations according to sex, according to the age groups 19 to 36 and 37 to 55 and according to BMI (normal, overweight, obese). Conclusion: In a context of limited resources, this study contributes to providing reference ranges with a view to improving the control and monitoring of diabetes mellitus in Burkinabe subjects.

Mots-clés

Fructosamine, Reference Values, Blood Donor, Bobo-Dioulasso