study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

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Résumé

Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-
inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and
their ability to inhibit phospholipase A2 and 15-lipoxygenase activity. The hydroethanolic extract of T.
macroptera revealed the strongest reducing power with an IC50 of 7.29 ± 0.61 µg/mL. The three most
active extracts on PLA2 were hydroethanolic extracts of C. tinctorium (IC50 of 21.43 ± 0.66 µg/mL), T.
macroptera (IC50 of 23.72 ± 0.71 µg/mL), X. americana (IC50 of 24.49 ± 0.39 µg/mL). The best inhibitory
activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of X. americana with
IC50 of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves
of T. macroptera and roots of X. americana have antioxidant activity and effectively inhibit sPLA2, and
15-LOX pro-inflammatory enzymes in vitro.
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Mots-clés

Phospholipase A2 Ximenia americana Terminalia macroptera Cochlospermum tinctorium Ximenia americana 15-lipoxygenase ABTS Mali.