Publications (155)
ARTICLE
The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels
Morgane Bayle, Jérémie Neasta, Margherita Dall'Asta, Guillaume Gautheron, Anne Virsolvy, Jean‐François Quignard, Estelle Youl, Richard Magous, Jean‐François Guichou, Alan Crozier, Daniele Del Rio, Gérard Cros, Catherine Oiry
Background and Purpose: The pharmacology of polyphenol metabolites on beta‐ cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the insulin‐secreting function of beta‐cells and to explore the underlying mechanisms.
Experimental Approach: INS‐1 beta‐cells and rat isolated islets of Langerhans or per(...)
ellagitannin, urolithin C, glucose‐dependent regulator, insulin secretion, L‐type calcium channels
ARTICLE
Antioxidant activity of crude ethanolic extract and fractions of Ziziphus mauritiana Lam. (Rhamnaceae) leaves from Burkina Faso.
Estelle Noëla Hoho YOUL, Cyrille A.P. Ouédraogo, Moustapha Gambo, Moussa Ouédraogo, Martin Kiendrebéogo, Aristide Traoré, Innocent Pierre Guissou
Background: Ziziphus mauritiana Lam. is a plant used in traditional medicine in Burkina Faso in the treatment of several diseases, of which diabetes is characterized by oxidative stress. The aim of this study was to evaluate the in vitro antioxidant potential of the extracts of leaves of this plant.
Methods: The crude hydroethanolic extract ((...)
antioxidant activity, polyphenol content, Ziziphus mauritiana
ARTICLE
Rosuvastatin and vascular oxidative stress induced by diesel exhaust particles
athalie Labranche , Estelle N. H. Youl , Charaf El Khattabi , Laurence Dewachter , Nathalie Wauthoz , Cédric Delporte , Guy Berkenboom & Stéphanie Pochet,
Objective Exposure to diesel exhaust particles (DEP) is strongly linked to the development and exacerbation of cardiovascular diseases. Statins are effective drugs in the prevention and treatment of cardiovascular disorders. The aim of this study was to investigate the potential protective effect of rosuvastatin on DEP-induced endothelial dysf(...)
Diesel exhaust particles, oxidative stress, statins, eNOS, NADPH oxidase
ARTICLE
POLYMORPHISME GENETIQUE DES CYTOCHROMES P450 : SYNTHESE METHODIQUE DES ETUDES PRIMAIRES EFFECTUEES DANS LA POPULATION AFRICAINE
ELIE KABRE, RAOUL KARFO, BOUKARE KASSONGO, JEAN SAKANDE , MAMADOU SAWADOGO
Il existe une grande variabilité interindividuelle de réponse aux médicaments, tant en terme d’efficacité que de toxicité. Pour comprendre cette variabilité, de multiples travaux de recherche sur le polymorphisme génétique des cytochromes P450 ont été menés de par le monde. Notre étude a pour but de faire le point des études réalisées en Afri(...)
: Pharmacogénétique, Polymorphisme, Cytochromes P450
ARTICLE
PRÉVALENCE ET CARACTÉRISTIQUES DES UTILISATIONS HORS MONOGRAPHIE DES MÉDICAMENTS EN PÉDIATRIE AU CENTRE HOSPITALIER UNIVERSITAIRE YALGADO OUÉDRAOGO (CHUYO), BURKINA FASO
ZONGO R. F. E ., DIALLO I., OUEDRAOGO S., BOUDA C. G., GAMBO O., YOUL N. E., GUISSOU I. P.
Introduction: l'usage du médicament en pédiatrie n'est pas toujours en accord avec la monographie approuvée par l'autorisation de mise sur le marché. La présente étude vise à déterminer la prévalence des utilisations hors monographie des médicaments dans le département de pédiatrie du CHUYO et de les décrire.
Méthodes: Une étude rétrospective(...)
Approbation du médicament, Monographie, Pédiatrie, Utilisation hors monographie
ARTICLE
ANALYSE DES ORDONNANCES MÉDICALES AU CENTRE HOSPITALIER UNIVERSITAIRE YALGADO OUEDRAOGO DE OUAGADOUGOU
FOFANA S., ZONGO F. E., ZOUNGRANA P. M., OUEDRAOGO M., YOUL E., GNOULA C., SONDE I., GUISSOU I. P.
Introduction
La prescription des médicaments est un acte médical spécialisé. De loi des médicaments. Afin de s au CHU YO, nous avons analysé la conformité règlementaire et technique des ordonnances médicales prescrites.
Méthodologie
Il s'agit d'une étude transversale descriptive menée entre avril et mai 2012 à l'officine pharmaceutique du C(...)
Prescription médicale; Pharmacie hospitalière; CHU- YO; Burkina Faso.
COMMUNICATION
Expérience du Burkina Faso en matière de pharmacovigilance
E. W. Ouédraogo1, E. Da/Nacoulma1, F. E. Zongo2, C. R. Ouandaogo3
Titre : Expérience du Burkina Faso en matière de pharmacovigilance
Auteurs : E. W. Ouédraogo1, E. Da/Nacoulma1, F. E. Zongo2, C. R. Ouandaogo3.
Introduction
Conformément à la résolution WHA.16.36 (16ème assemblée mondiale de la santé) de 1963, le Burkina Faso s’est engagé résolument en 2006 à la faveur de l’introduction des ACT dans la pri(...)
Pharmacovigilance, Burkina Faso
ARTICLE
Determination of groundwater mercury (II) content using a disposable gold modified screen printed carbon electrode
Touridomon Issa Some, Abdoul Karim Sakira, Dominique Mertens, Sebastien N. Ronkartand Jean-Michel Kauffmann
Mercury (II) measurements were performed thanks to a newly developed electrochemical method using a disposable gold modified screen printed carbon electrode. The method has a wide dynamic range (1–100 µg/L), a good accuracy and a limit of detection in compliance with WHO standards. The application of the method to several groundwater samples m(...)
Mots clés non renseignés
COMMUNICATION
Using new vaccine introduction as entry point for strengthening AEFI surveillance systems Lessons learned with MenAfriVac® in Burkina Faso
Dr Emile W. OUEDRAOGO
Dr Emile Ouédraogo of Burkina Faso reported how the introduction of a new vaccine – the meningitis vaccine MenAfriVac – provided an opportunity to strengthen the country’s AEFI surveillance system. Prior to this, training on spontaneous reporting of adverse drug reactions for malaria and HIV/TB medicines had been funded by the Global Fund, and(...)
AEFI, Vaccine, Burkina Faso, MenAfrivac
ARTICLE
MAP Kinase cross talks in oxidative stress-induced impairment of insulin secretion. Involvement in the protective activity of quercetin
Estelle Youl, Richard Magous, Gerard Cros, Catherine Oiry
Insulin secretion preservation is a major issue for the prevention or treatment of type 2 diabetes. We previously showed on b-cells that quercetin (Q), but not resve- ratrol (R) or N-acetyl cysteine (NAC), amplified glucose-induced insulin secretion in a calcium- and ERK1/2-dependent manner. Quercetin, but not resveratrol or NAC, also protecte(...)
Insulin secretion, MAP kinase cross talks, oxidative stress, quercetin, b-cell
ARTICLE
Determination of arsenic (III) at a nanogold modified solid carbon paste electrode
Abdoul Karim Sakira, Touridomon Issa Some, Bieke Dejaegher, Dominique Mertens, Philippe Hubert, Eric M Ziemons and Jean‐Michel Kauffmann
A selective and sensitive electroanalytical method was developed for arsenic determination based on a nanogold (AuNP) modified solid carbon paste working electrode (SCPE) modified in two steps (i) physisorption and (ii) additional electrodeposition of nanogold particles in the presence of iodide. Copper (II) interference was solved by covering(...)
Mots clés non renseignés
ARTICLE
Determination of β-carotene by High Performance Liquid Chromatography in Six Varieties of Mango (Mangifera indica L) from Western Region of Burkina Faso
Touridomon Issa Somé, Abdoul Karim Sakira and Eric Dofinizoumou Tamimi
Six varieties of mangoes (Amelia, Brooks, Kent, Keitt, Lippens, Springfield) harvested from different pedological areas of the western region of Burkina Faso (Bobo-Dioulasso, Orodara, Banfora) were analyzed by high performance liquid chromatography in order to determine the β-carotene content. The study revealed a variability in β-carotene con(...)
Mots clés non renseignés
ARTICLE
Effect of cyclodextrins on artemisinin stability and in vitro dissolution
H Zime-Diawara, F Gbaguidi, R Semde, I Some, J Quetin-Leclercq, M Moudachirou, G Piel and B Evrard
Artemisinin is extracted from the Asian plant Artemisia annua L. It has been proven to be, with its derivatives, the molecules that have shown so far the most powerful activity on malaria, even in its complicated forms and resistance cases. To resolve the problem of low aqueous solubility of this molecule, the use of cyclodextrins (CDs) was en(...)
Mots clés non renseignés
ARTICLE
Arsenic levels in tube-wells water, food, residents' urine and the prevalence of skin lesions in Yatenga province, Burkina Faso
Issa T. Somé,1 Abdoul K. Sakira, Moustapha Ouédraogo, Theodore Z. Ouédraogo, Adama Traoré, Blaise Sondo and Pierre I. Guissou2
The aim of the present study was to evaluate the levels of arsenic in tube-well water, food and residents' urines samples in Yatenga province, Burkina Faso. The prevalence of skin lesions was evaluated as well. The study was cross-sectional in design. It was conducted during April 2009. Permanent residents of 20 villages were included in the s(...)
Mots clés non renseignés
ARTICLE
Quercetin potentiates insulin secretion and protects INS-1 pancreatic b-cells against oxidative damage via the ERK1/2 pathway
E Youl, G Bardy, R Magous, G Cros, F Sejalon, A Virsolvy, S Richard, JF Quignard, R Gross, P Petit, D Bataille and C Oiry
BACKGROUND AND PURPOSE
Quercetin lowers plasma glucose, normalizes glucose tolerance tests and preserves pancreatic b-cell integrity in diabetic rats. However, its mechanism of action has never been explored in insulin-secreting b-cells. Using the INS-1 b-cell line, the effects of quercetin were determined on glucose- or glibenclamide-induced(...)
quercetin; pancreatic b-cells; insulin secretion; cell viability; ERK1/2; oxidative stress; diabetes